![]() ![]() ![]() After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea. Lufenuron’s mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient, Sentinel Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonine) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in Sentinel Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Benzozylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). Lufenuron is a benozylphenylurea derivative with the following chemical composition: N-2,6- difluorobenzamide (C 17H 8Cl 2F 8N 2O 3, MW 511.15). Milbemycin oxime is classified as a macrocyclic anthelmintic. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A 4 (C 32H 45NO 7, MW 555.71) and 20% A 3 (C 31H 43NO 7, MW 541.68). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. Sentinel Flavor Tabs are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. Keep this and all drugs out of the reach of children. ![]()
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